Selected Publications

2026

IL-22 promotes genesis of small intestinal secretory cells that protect against cholera in mice
Suzuki M, Hasegawa Y, Zhang H, Liang Z, Tie G, Shivdasani RA, Waldor MK.
Nature Microbiology. 2026;11:1949–1966.
DOI: 10.1038/s41564-026-02375-7

Quantifying host-microbe interactions with bacterial lineage tracing
Campbell IW, Hullahalli K, Waldor MK.
Science. 2026;391:34–40.
DOI: 10.1126/science.adx5362

Safety and immunogenicity of PanChol, a single-dose live-attenuated oral cholera vaccine: results from a phase 1a, double-blind, randomised, placebo-controlled trial
Leitner DR, Walsh SR, Suzuki M, et al.; PanChol Study Group.
The Lancet Infectious Diseases. 2026;26:497–509.
DOI: 10.1016/S1473-3099(25)00682-6

Vibrio cholerae serotype impacts pathogenicity
Zingl FG, Leitner DR, Fakoya B, Morano AA, Waldor MK.
Nature Communications. 2026;17:1140.
DOI: 10.1038/s41467-025-67908-w

2025

Anoxia activates CRISPR-Cas immunity in the mouse intestine
Campbell IW, Basta DW, Zingl FG, Sullivan EJ, Doranga S, Waldor MK.
Nature Microbiology. 2025;10:3069–3074.
DOI: 10.1038/s41564-025-02172-8

Vibrio cholerae motility is associated with inter-animal transmission
Campbell IW, Dehinwal R, Morano AA, Dailey KG, Zingl FG, Waldor MK.
Nature Communications. 2025;16:7989.
DOI: 10.1038/s41467-025-62984-4

Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice
Basta DW, Campbell IW, Sullivan EJ, Hotinger JA, Hullahalli K, Garg M, Waldor MK.
Nature Microbiology. 2025;10:1171–1183.
DOI: 10.1038/s41564-025-01975-z

The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase
Leitner DR, Zingl FG, Morano AA, Zhang H, Waldor MK.
mBio. 2025;16:e0343324.
DOI: 10.1128/mbio.03433-24

2024

Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis
Zhang T, Hasegawa Y, Waldor MK.
Nature Microbiology. 2024;9:3376–3390.
DOI: 10.1038/s41564-024-01862-z

Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling
Zhang H, Hasegawa Y, Suzuki M, Zhang T, Leitner DR, Jackson RP, Waldor MK.
Nature Communications. 2024;15:9237.
DOI: 10.1038/s41467-024-53545-2

Peripheral serotonergic neurons regulate gut motility and anxiety-like behavior
Zhang H, Leitner DR, Hasegawa Y, Waldor MK.
Current Biology. 2024;34:R133–R134.
DOI: 10.1016/j.cub.2023.12.072

Preprints

Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics
Basta DW, Zingl FG, Yang Y, Nguyen KT, Liu YY, Waldor MK.
bioRxiv. 2025.
MultiCAST: a scalable platform for guide RNA-directed transposon insertion and high-throughput reverse genetics.
DOI: 10.1101/2025.10.31.685825

AI-guided discovery of antimicrobial peptides for urinary tract infections leveraging a new catalogue of the human urinary microbiome
Ke S, Zingl FG, Wang XW, Hale VL, Weiss ST, Waldor MK, Liu YY.
bioRxiv. 2026.
DOI: 10.64898/2026.08.05.741749